Dvorin Lab, Boston Children's Hospital and Harvard Medical School

2019

Clements RL, Streva V, Dumoulin P, Huang W, Owens E, Raj DK, Burleigh B, Llinás M, Winzeler EA, Zhang Q, Dvorin JD. A novel antiparasitic compound kills ring-stage Plasmodium falciparum and retains activity against artemisinin-resistant parasites. The Journal of Infectious Diseases 2019; ePub ahead of print.

Rudlaff RM, Kraemer S, Streva VA, Dvorin JD. An essential contractile ring protein controls cell division in Plasmodium falciparum. Nature Communications 2019; 10: 2181.

2018

Absalon S, Blomqvist K, Rudlaff RM, DeLano TJ, Pollastri MP, Dvorin JD. Calcium-Dependent Protein Kinase 5 is Required for Release of Egress-Specific Organelles in Plasmodium falciparum. mBio; 9(1): e00130-10.

2017

Robbins, JA, Absalon S, Streva VA, Dvorin JD.

The Malaria Parasite Cyclin H Homolog PfCyc1 Is Required for Efficient Cytokinesis in Blood-Stage Plasmodium falciparum. mBio; 8(3): e00605-17 

Dvorin JD. Getting Your Head around Cerebral Malaria. Cell Host Microbe; 22(5): 586-8.

2016

Absalon S, Robbins JA, Dvorin JD.

An essential malaria protein defines the architecture of blood-stage and transmission-stage parasites. Nature Communications, 2016;7:11449

Blomqvist K, DiPetrillo C, Streva, VA, Pine S, Dvorin JD.

Receptor for Activated C-Kinase 1 (PfRACK1) is required for Plasmodium falciparum intra-erythrocytic proliferation. Molecular and Biochemical Parasitology, 2016; 16.

2015

Sun M, Li W, Blomqvist K, Das S, Hashem Y, Dvorin JD, Frank J.

Dynamical features of the Plasmodium falciparum ribosome during translation. Nucleic Acids Research 2015;43(21):10515-24

 

2014
Raj DK, Nixon CP, Nixon CE, Dvorin JD, DiPetrillo CG, Pond-Tor S, Wu HW, Jolly G, Pischel L, Lu A, Michelow IC, Cheng L, Conteh S, McDonald EA, Absalon S, Holte SE, Friedman JF, Fried M, Duffy PE, Kurtis JD. Antibodies to PfSEA-1 block parasite egress from RBCs and protect against malaria infection. Science 2014; 344(6186):871-7

Dvorin JD. Inside scoop on outside proteins. Infection and Immunity 2014; 82(3):921-3

2013

Farrell A*, Thirugnanam S*, Lorestani A*, Dvorin JD*, Eidell KP, Ferguson DJP, Anderson-White BR, Duraisingh MT, Marth GT, Gubbels M-J. A DOC2 Protein Identified by Mutational Profiling is Essential for Apicomplexan Parasite Exocytosis. Science, 2012; 335(6065): 218-21.

* Co-first authors

2010

Dvorin JD, Martyn DC, Patel SD, Grimley JS, Collins CR, Hopp CS, Bright AT, Westenberger S, Winzeler E, Blackman MJ, Baker DA, Wandless TJ, Duraisingh MT. A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes. Science 2010; 328(5980): 910-912.

 

Dvorin JD, Bei AK, Coleman BI, Duraisingh MT. Functional diversification between two related Plasmodium falciparum merozoite invasion ligands is determined by changes in the cytoplasmic domain. Molecular Microbiology 2010; 75(4): 990-1006.

Pre-2010

Bushkin GG, Ratner DM, Cui J, Banerjee S, Duraisingh M, Jennings C, Dvorin JD, Gubbels MJ, Robertson S, Steffen M, O’Keefe BR, Robbins PW, Samuleson J. Suggestive evidence for Darwinian selection against asparagine-linked glycans of Plasmodium and Toxoplasma. Eukaryotic Cell 2009; 9(2): 228-241.

Dong C, Patel V, Yang JC, Dvorin JD, Duraisingh MT, Clardy J, Wirth DF. Type II NADH dehydrogenase of the respiratory chain ofPlasmodium falciparum and its inhibitors. Bioorganic & Medicinal Chemistry Letters 2009; 19: 972-975.

 

Patel V, Booker M, Kramer M, Ross L, Celatka CA, Kennedy LM, Dvorin JD, Duraisingh MT, Sliz P, Wirth DF, Clardy J. Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. Journal of Biological Chemistry 2008; 283(50): 35078-35085.

 

Estivariz CF, Park SY, Hageman JC, Dvorin JD, Melish MM, Arpon R, Coon P, Slavish S, Kim M, McDougal LK, Jensen B, McAllister S, Lonsway D, Killgore G, Effler PE, Jernigan DB. Emergence of community-associated methicillin resistant Staphylococcus aureus in Hawaii, 2001-2003. Journal of Infection 2007; 54: 349-357.

 

Dvorin JD, Bell P, Maul GG, Yamashita M, Emerman M, Malim MH.  Reassessment of the roles of integrase and the central DNA flap in human immunodeficiency virus type 1 nuclear import. Journal of Virology 2002; 76(23): 12087-12096.

 

Bouyac-Bertoia M*, Dvorin JD*, Fouchier RAM, Jenkins J, Meyer BE, Wu LI, Emerman M, Malim MH. HIV-1 infection requires a functional integrase NLS. Molecular Cell 2001; 7: 1025-1035. 

* Co-first authors

 

Fultz PN, Vance PJ, Endres MJ, Tao B, Dvorin JD, Davis IC, Lifson JD, Montefiori DC, Marsh M, Malim MH, Hoxie JA.  In vivo attenuation of simian immunodeficiency virus by disruption of a tyrosine-dependent sorting signal in the envelope glycoprotein cytoplasmic tail. Journal of Virology 2001; 75(1): 278-291.